Best Performance by an Actress in a Motion Picture - Comedy or Musical - Annette Bening - Running With Scissors
- Toni Collette - Little Miss Sunshine
- Beyoncé Knowles - Dreamgirls
- Meryl Streep - The Devil Wears Prada
- Renée Zellweger - Miss Potter
| Best Performance by an Actor in a Motion Picture - Comedy or Musical - Sacha Baron Cohen - Borat
- Johnny Depp - Pirates of the Caribbean: Dead Man's Chest
- Aaron Eckhart - Thank You for Smoking
- Chiwetel Ejiofor - Kinky Boots
- Will Ferrell - Stranger Than Fiction
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